the current textual content is a whole revision of the second variation from 2003 of the publication with a similar identify. In reputation of the quick speed at which biotechnology is relocating we now have rewritten a number of chapters to incorporate new clinical growth within the box from 2000 to 2010. extra very important now we have replaced the focal point of the publication to help its use, not just in universities, but additionally as a consultant to layout new procedures and gear within the bio-industry. a brand new bankruptcy has been incorporated at the clients of the bio-refinery to interchange a few of the oil- and fuel dependent procedures for creation of specially bulk chemical compounds. This bankruptcy additionally serves to make scholars in Chemical Engineering and within the Bio-Sciences passionate about the full study box. As in past variations we are hoping that the e-book can be utilized as textbook for sessions, even on the undergraduate point, the place chemical engineering scholars come to paintings facet through facet with scholars from biochemistry and microbiology. to assist the chemical engineering scholars bankruptcy 1 features a short assessment of crucial components of microbial metabolism. In our opinion this assessment is enough to comprehend microbial body structure at a sufficiently excessive point to benefit from the remainder of the publication. Likewise the bio-students usually are not crushed through arithmetic, yet because the goal of the publication is to coach quantitative strategy research and technique layout at a hands-on point a few arithmetic and version research is required. we are hoping that the approximately a hundred specified examples and textual content notes, including many instructive difficulties might be adequate to demonstrate how version research is used, additionally in Bio-reaction Engineering.